Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → 3-[(5-Bromo-2-chloro-pyrimidin-4-yl)-propan-2-yl-amino]-N-methyl-propanamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 5-Bromo-2,4-dichloropyrimidine | HCID 289973 | — |
| 반응물 | 3-(Isopropylamino)-N-methylpropanamide | HCID 28307158 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | 3-[(5-Bromo-2-chloro-pyrimidin-4-yl)-propan-2-yl-amino]-N-methyl-propanamide | HCID 86617567 | 78% |
반응 단계
5-Bromo-2,4-dichloropyrimidine (1.83 g, 8.00 mmol), N-methyl-3-(propan-2-ylamino)propanamide (Intermediate 14, 1.16 g, 8.00 mmol) and Et3N (1.2 mL, 8.16 mmol) were combined in MeCN (50 mL) and shaken at ambient temperature for 3 days before the solvent was removed under reduced pressure. Purification by column chromatography (SiO2, eluent gradient 2-10% MeOH to DCM) to afford the title compound (2.08 g, 78%) as a gum.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07709471B2 |
| 출처 데이터셋 | uspto-grants-2010_05 |
| ORD ID | ord-2f21a35b607441999b26f4ec50a58342 |
| 출처 메모 | uspto-grants-2010_05 |