Isopropylamine → 3-(Isopropylamino)-N-methylpropanamide

HRID 2234353노트

반응식

HRID 2234353 반응식
[CH3:1][NH:2][C:3](=[O:6])[CH:4]=[CH2:5].[CH:7]([NH2:10])([CH3:9])[CH3:8]>CO>[CH3:1][NH:2][C:3](=[O:6])[CH2:4][CH2:5][NH:10][CH:7]([CH3:9])[CH3:8]

참가 물질

4

반응물 2

HCID 6363IsopropylamineHCID 14471Methylacrylamide

생성물 1

HCID 283071583-(Isopropylamino)-N-methylpropanamide수율 108.2%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

N-Methylacrylamide (851 mg, 10.00 mmol) and isopropylamine (1.71 mL, 1.18 g, 20.00 mmol) in MeOH (10 mL) were irradiated to 140° C. for 30 mins in a microwave reaction vessel. The reaction mixture was cooled and loaded onto a SCX-2 column and washed with MeOH (100 mL). The crude product was then eluted from the SCX-2 column with NH3 (100 mL, 7M in MeOH) and the volatiles removed under reduced pressure to afford the title compound (1.56 g, Quant.) as an oil, which was used without further purification.

후처리

  1. temperatureThe reaction mixture was cooled
  2. washwashed with MeOH (100 mL)
  3. washThe crude product was then eluted from the SCX-2 column with NH3 (100 mL, 7M in MeOH)
  4. customthe volatiles removed under reduced pressure

출처 및 근거

ORD 기록
ord-ce21c49885d04195b9b23c29f45735d7
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07709471B2

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