N-(3-dimethylamino-2,2-dimethyl-propyl)-3-methoxy-4-nitro-benzamide → 4-amino-N-(3-dimethylamino-2,2-dimethyl-propyl)-3-methoxy-benzamide

HRID 2234354노트

반응식

HRID 2234354 반응식
[CH3:1][N:2]([CH3:22])[CH2:3][C:4]([CH3:21])([CH3:20])[CH2:5][NH:6][C:7](=[O:19])[C:8]1[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[C:10]([O:17][CH3:18])[CH:9]=1>CCO.[Pd]>[NH2:14][C:11]1[CH:12]=[CH:13][C:8]([C:7]([NH:6][CH2:5][C:4]([CH3:20])([CH3:21])[CH2:3][N:2]([CH3:1])[CH3:22])=[O:19])=[CH:9][C:10]=1[O:17][CH3:18]

참가 물질

4

반응물 1

HCID 68685548N-(3-dimethylamino-2,2-dimethyl-propyl)-3-methoxy-4-nitro-benzamide2회

생성물 1

HCID 592951104-amino-N-(3-dimethylamino-2,2-dimethyl-propyl)-3-methoxy-benzamide수율 104.3%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

반응 조건

온도
40 °C

실험 절차

A suspension of N-(3-dimethylamino-2,2-dimethyl-propyl)-3-methoxy-4-nitro-benzamide (Intermediate 23; 5.7 g, 18.40 mmol), 5% Pd on charcoal (569 mg) in EtOH (300 mL) was stirred at 40° C. under a hydrogen atmosphere for 16 h. The reaction mixture was then filtered through celite, washed with copious MeOH and the volatiles removed under reduced pressure to afford the title compound (5.36 g, Quant.) as a foam.

후처리

  1. filtrationThe reaction mixture was then filtered through celite
  2. washwashed with copious MeOH
  3. customthe volatiles removed under reduced pressure

출처 및 근거

ORD 기록
ord-c80c79f728ad48729456c07f8c630038
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07709471B2

반응 노트

불러오는 중…