Ethanol → 3-[(2-Methoxyethyl)amino]-N-methylpropanamide

HRID 2234409

반응식

HRID 2234409 반응식
[CH3:1][NH:2][C:3](=[O:6])[CH:4]=[CH2:5].[CH3:7][O:8][CH2:9][CH2:10][NH2:11].CCO>CO>[CH3:7][O:8][CH2:9][CH2:10][NH:11][CH2:5][CH2:4][C:3]([NH:2][CH3:1])=[O:6]

참가 물질

5

반응물 3

HCID 702EthanolHCID 80182-MethoxyethylamineHCID 14471Methylacrylamide

생성물 1

HCID 283071863-[(2-Methoxyethyl)amino]-N-methylpropanamide수율 65%

시약·촉매·용매 1

HCID 887Methanol용매

반응 조건

온도
140 °C

실험 절차

N-Methylacrylamide (ABCR; 500 mg, 5.87 mmol), 2-Methoxyethylamine (Aldrich; 441 mg, 5.87 mmol), and EtOH (2 mL) were combined and heated in a microwave at 140° C. for 40 minutes. The reaction mixture was cooled and added to a 5 g SCX-2 column pre-wet with MeOH (2 column volumes), flushed with MeOH (2 column volumes) then the product eluted with 2M ammonia in MeOH. Product containing fractions were evaporated in vacuo to give the title compound as a clear oil (608 mg, 65%)

후처리

  1. temperatureThe reaction mixture was cooled
  2. customflushed with MeOH (2 column volumes)
  3. washthe product eluted with 2M ammonia in MeOH
  4. additionProduct containing fractions
  5. customwere evaporated in vacuo

출처 및 근거

ORD 기록
ord-542e4945d87a4bf388dd5870b467d054
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07709471B2

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