N-(1-ethyl-4-piperidyl)-3-methoxy-4-nitro-benzamide → 4-amino-N-(1-ethyl-4-piperidyl)-3-methoxy-benzamide

반응식

NC1C=CC(C(NC2CCN(C)C2)=O)=CC=1OC.[CH2:19]([N:21]1[CH2:26][CH2:25][CH:24]([NH:27][C:28](=[O:40])[C:29]2[CH:34]=[CH:33][C:32]([N+:35]([O-])=O)=[C:31]([O:38][CH3:39])[CH:30]=2)[CH2:23][CH2:22]1)[CH3:20]>>[NH2:35][C:32]1[CH:33]=[CH:34][C:29]([C:28]([NH:27][CH:24]2[CH2:23][CH2:22][N:21]([CH2:19][CH3:20])[CH2:26][CH2:25]2)=[O:40])=[CH:30][C:31]=1[O:38][CH3:39]

참가 물질

반응물 2

HCID 68681536N-(1-ethyl-4-piperidyl)-3-methoxy-4-nitro-benzamide2회

HCID 686841234-amino-3-methoxy-N-(1-methylpyrrolidin-3-yl)benzamide

생성물 1

HCID 580150934-amino-N-(1-ethyl-4-piperidyl)-3-methoxy-benzamide

실험 절차

The title compound was prepared in quantitative yield by an analogous method to the preparation of Intermediate 187, on a 2 g scale utilising N-(1-ethyl-4-piperidyl)-3-methoxy-4-nitro-benzamide (Intermediate 191).

출처 및 근거

ORD 기록: ord-8f69364c5a0d432089c8a5d9111f677e
출처 데이터셋: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07709471B2

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