Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(4-Fluorophenyl)piperazine → 8-{3-[4-(4-fluorophenyl)-1-piperazinyl]propoxy}-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(4-Fluorophenyl)piperazine | HCID 75260 | — |
| 반응물 | Fumarate | HCID 5460307 | — |
| 반응물 | 2,3-dihydro-8-[3-(methanesulfonyloxy)propoxy]-7-methoxy-cyclopenta[c][1]-benzopyran-4(1H)-one | HCID 19927662 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 8-{3-[4-(4-fluorophenyl)-1-piperazinyl]propoxy}-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927713 | 84% |
반응 단계
Method B (12 h at 55° C.); starting materials: 2,3-dihydro-8-[3-(methanesulfonyloxy)propoxy]-7-methoxy-cyclopenta[c][1]-benzopyran-4(1H)-one (example 82) and 1-(4-fluorophenyl)piperazine; yield 84%; fusion point 139°-141° C. (from ethanol). Fumarate: method E; yield 90%; fusion point 195°-200° C. (from ethanol).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05428038 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-a9cd8dfe7fff459989a271e227763bd8 |
| 출처 메모 | uspto-grants-1995_06 |