Ethanol → 8-{3-[4-(2,3-dimethylphenyl)-1-piperazinyl]propoxy}-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one

HRID 22346

반응식

HRID 22346 반응식
CS(O[CH2:6][CH2:7][CH2:8][O:9][C:10]1[C:11]([O:24][CH3:25])=[CH:12][C:13]2[O:18][C:17](=[O:19])[C:16]3[CH2:20][CH2:21][CH2:22][C:15]=3[C:14]=2[CH:23]=1)(=O)=O.[CH3:26][C:27]1[C:32]([CH3:33])=[CH:31][CH:30]=[CH:29][C:28]=1[N:34]1[CH2:39][CH2:38][NH:37][CH2:36][CH2:35]1.C(O)C.C([O-])(=O)/C=C/C([O-])=O>CC(C)=O>[CH3:26][C:27]1[C:32]([CH3:33])=[CH:31][CH:30]=[CH:29][C:28]=1[N:34]1[CH2:35][CH2:36][N:37]([CH2:6][CH2:7][CH2:8][O:9][C:10]2[C:11]([O:24][CH3:25])=[CH:12][C:13]3[O:18][C:17](=[O:19])[C:16]4[CH2:20][CH2:21][CH2:22][C:15]=4[C:14]=3[CH:23]=2)[CH2:38][CH2:39]1

참가 물질

6

반응물 4

HCID 702EthanolHCID 705411-(2,3-Xylyl)piperazineHCID 5460307FumarateHCID 199276622,3-dihydro-8-[3-(methanesulfonyloxy)propoxy]-7-methoxy-cyclopenta[c][1]-benzopyran-4(1H)-one

생성물 1

HCID 199276678-{3-[4-(2,3-dimethylphenyl)-1-piperazinyl]propoxy}-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one수율 84%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Method B (20 h at 60° C.); starting materials: 2,3-dihydro-8-[3-(methanesulfonyloxy)propoxy]-7-methoxy-cyclopenta[c][1]-benzopyran-4(1H)-one (example 82) and 1-(2,3-dimethylphenyl)-piperazine; yield 84%; fusion point 164°-166° C. (from ethanol). Fumarate: method E; yield 94%; fusion point 235°-237° C. (from acetone).

후처리

  1. customMethod B (20 h at 60° C.)

출처 및 근거

ORD 기록
ord-e5882c6c7f6c406183c260764bcc471d
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05428038

연결된 노트

불러오는 중…