Ethanol → 2,3-dihydro-7-methoxy-8-{3-[4-(3-methoxyphenyl)-1-piperazinyl]propoxy}cyclopenta[c][1]benzopyran-4(1H)-one

HRID 22348

반응식

HRID 22348 반응식
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[C:7]([O:20][CH3:21])=[CH:8][C:9]2[O:14][C:13](=[O:15])[C:12]3[CH2:16][CH2:17][CH2:18][C:11]=3[C:10]=2[CH:19]=1.[CH3:22][O:23][C:24]1[CH:25]=[C:26]([N:30]2[CH2:35][CH2:34][NH:33][CH2:32][CH2:31]2)[CH:27]=[CH:28][CH:29]=1.C(O)C.C([O-])(=O)/C=C/C([O-])=O>CC(C)=O.C(O)(C)C>[CH3:21][O:20][C:7]1[C:6]([O:5][CH2:4][CH2:3][CH2:2][N:33]2[CH2:32][CH2:31][N:30]([C:26]3[CH:27]=[CH:28][CH:29]=[C:24]([O:23][CH3:22])[CH:25]=3)[CH2:35][CH2:34]2)=[CH:19][C:10]2[C:11]3[CH2:18][CH2:17][CH2:16][C:12]=3[C:13](=[O:15])[O:14][C:9]=2[CH:8]=1

참가 물질

7

반응물 4

HCID 702EthanolHCID 81430N-(3-methoxyphenyl)piperazineHCID 5460307FumarateHCID 199276908-(3-chloropropoxy)-2,3-dihydro-7-methoxycyclopenta[c][1]benzopyran-4(1H)-one

생성물 1

HCID 199276792,3-dihydro-7-methoxy-8-{3-[4-(3-methoxyphenyl)-1-piperazinyl]propoxy}cyclopenta[c][1]benzopyran-4(1H)-one수율 58%

시약·촉매·용매 2

HCID 180Acetone용매HCID 3776Isopropanol용매

실험 절차

Method B (60 h at 50° C.); starting materials: 8-(3-chloropropoxy)-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one (example 83) and 1-(3-methoxyphenyl)piperazine; yield 58%; fusion point 130°-132° C. (from ethanol and isopropanol). Fumarate: method E; yield 80%; fusion point 174°-175° C. (from acetone).

후처리

  1. customMethod B (60 h at 50° C.)

출처 및 근거

ORD 기록
ord-eb759a0b34b746ed8ab96923d5d5c27c
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05428038

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