4-Bromo-3-fluorobenzenesulfonyl chloride → 4-Bromo-N-{5-[cis-3,5-dimethyl-1-piperazinyl]-3-pyridinyl}-3-fluorobenzenesulfonamide
반응식
BrC1C=CC(S(NC2C=CN=C(Cl)C=2)(=O)=O)=CC=1.[CH3:19][C@H:20]1[NH:25][C@@H:24]([CH3:26])[CH2:23][N:22]([C:27]2[CH:28]=[C:29]([NH2:33])[CH:30]=[N:31][CH:32]=2)[CH2:21]1.[Br:34][C:35]1[CH:40]=[CH:39][C:38]([S:41](Cl)(=[O:43])=[O:42])=[CH:37][C:36]=1[F:45]>>[Br:34][C:35]1[CH:40]=[CH:39][C:38]([S:41]([NH:33][C:29]2[CH:30]=[N:31][CH:32]=[C:27]([N:22]3[CH2:23][C@H:24]([CH3:26])[NH:25][C@H:20]([CH3:19])[CH2:21]3)[CH:28]=2)(=[O:43])=[O:42])=[CH:37][C:36]=1[F:45]참가 물질
4
실험 절차
The title compound was prepared in a manner similar to 4-bromo-N-(2-chloro-4-pyridinyl)benzenesulfonamide (D3) using 5-[cis-3,5-dimethyl-1-piperazinyl]-3-pyridinamine (D36) and 4-bromo-3-fluorobenzenesulfonyl chloride as the starting materials.