Isopropanol → 8-{3-[4-(2-ethoxyphenyl)-1-piperazinyl]propoxy}-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one

HRID 22350

반응식

HRID 22350 반응식
Cl[CH2:2][CH2:3][CH2:4][O:5][C:6]1[C:7]([O:20][CH3:21])=[CH:8][C:9]2[O:14][C:13](=[O:15])[C:12]3[CH2:16][CH2:17][CH2:18][C:11]=3[C:10]=2[CH:19]=1.Cl.[CH2:23]([O:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[N:32]1[CH2:37][CH2:36][NH:35][CH2:34][CH2:33]1)[CH3:24].C(O)(C)C.C([O-])(=O)/C=C/C([O-])=O>CC(C)=O>[CH2:23]([O:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[N:32]1[CH2:33][CH2:34][N:35]([CH2:2][CH2:3][CH2:4][O:5][C:6]2[C:7]([O:20][CH3:21])=[CH:8][C:9]3[O:14][C:13](=[O:15])[C:12]4[CH2:16][CH2:17][CH2:18][C:11]=4[C:10]=3[CH:19]=2)[CH2:36][CH2:37]1)[CH3:24]

참가 물질

6

반응물 4

HCID 3776IsopropanolHCID 5460307FumarateHCID 128624181-(2-Ethoxyphenyl)piperazine HydrochlorideHCID 199276908-(3-chloropropoxy)-2,3-dihydro-7-methoxycyclopenta[c][1]benzopyran-4(1H)-one

생성물 1

HCID 199276708-{3-[4-(2-ethoxyphenyl)-1-piperazinyl]propoxy}-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one수율 72%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

Method B (40 h at 50° C.); starting materials: 8-(3-chloropropoxy)-2,3-dihydro-7-methoxycyclopenta[c][1]benzopyran-4(1H)-one (example 83) and 1-(2-ethoxyphenyl)piperazine hydrochloride; yield 72%; fusion point 169°-170° C. (from isopropanol). Fumarate: method E; yield 85%; fusion point 159°-161° C. (from acetone).

후처리

  1. customMethod B (40 h at 50° C.)

출처 및 근거

ORD 기록
ord-421451103625430ab5a0df477f7eea04
출처 데이터셋
uspto-grants-1995_06
특허 번호
US05428038

연결된 노트

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