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4-(Aminomethyl)cyclohexanecarboxylic acid → 4-[(4,5-Diphenylpyrimidin-2-ylamino)methyl]cyclohexanecarboxylic acid

HRID 2235001
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HRID 2235001 반응식
C(=O)([O-])[O-].[Cs+].[Cs+].[NH2:7][CH2:8][CH:9]1[CH2:14][CH2:13][CH:12]([C:15]([OH:17])=[O:16])[CH2:11][CH2:10]1.Cl[C:19]1[N:24]=[C:23]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:22]([C:31]2[CH:36]=[CH:35][CH:34]=[CH:33][CH:32]=2)=[CH:21][N:20]=1>C1(C)C=CC=CC=1>[C:25]1([C:23]2[C:22]([C:31]3[CH:32]=[CH:33][CH:34]=[CH:35][CH:36]=3)=[CH:21][N:20]=[C:19]([NH:7][CH2:8][CH:9]3[CH2:10][CH2:11][CH:12]([C:15]([OH:17])=[O:16])[CH2:13][CH2:14]3)[N:24]=2)[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1
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참가 물질

5

반응물 3

HCID 55264-(Aminomethyl)cyclohexanecarboxylic acidHCID 10796Cesium carbonateHCID 126742762-Chloro-4,5-diphenylpyrimidine

생성물 1

HCID 236526954-[(4,5-Diphenylpyrimidin-2-ylamino)methyl]cyclohexanecarboxylic acid수율 62.2%

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

550 mg (1.69 mmol) of cesium carbonate were added to a suspension of 133 mg (0.84 mmol) of 4-aminomethylcyclohexanecarboxylic acid in 5 ml of toluene, and the mixture was stirred at room temperature. After 30 minutes, 150 mg (0.56 mmol) of 2-chloro-4,5-diphenyl-pyrimidine were added, and the mixture was stirred at 120° C. for 31 hours. The solvent was removed in vacuo and the residue was mixed with dichloromethane and water. The resulting precipitate was filtered off with suction. 135 mg (62%) of the desired product were obtained.

후처리

  1. stirringthe mixture was stirred at 120° C. for 31 hours
  2. customThe solvent was removed in vacuo
  3. additionthe residue was mixed with dichloromethane and water
  4. filtrationThe resulting precipitate was filtered off with suction

출처 및 근거

ORD 기록
ord-2c2c878a42fe493b989ccf7d23c40323
출처 데이터셋
uspto-grants-2010_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07713988B2

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