Ethanol → HCID 68439912, 화합물

HRID 2235041노트

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HRID 2235041 반응식
[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:27])=[C:15]([N:19]4[CH2:22][CH:21]([NH:23][CH:24]([CH3:26])[CH3:25])[CH2:20]4)[C:16]=3[Br:18])[C:11](=[O:28])[C:10]([C:29]([OH:31])=[O:30])=[CH:9]2)[C:5]([F:32])=[CH:4][C:3]=1[F:33].[C:34]([OH:41])(=[O:40])/[CH:35]=[CH:36]\[C:37]([OH:39])=[O:38].C(O)C>O>[C:34]([OH:41])(=[O:40])/[CH:35]=[CH:36]\[C:37]([OH:39])=[O:38].[NH2:1][C:2]1[N:7]=[C:6]([N:8]2[C:17]3[C:12](=[CH:13][C:14]([F:27])=[C:15]([N:19]4[CH2:20][CH:21]([NH:23][CH:24]([CH3:26])[CH3:25])[CH2:22]4)[C:16]=3[Br:18])[C:11](=[O:28])[C:10]([C:29]([OH:31])=[O:30])=[CH:9]2)[C:5]([F:32])=[CH:4][C:3]=1[F:33]

참가 물질

5

반응물 3

HCID 702EthanolHCID 444266Maleic AcidHCID 68439913HCID 68439913, 화합물

생성물 1

HCID 68439912HCID 68439912, 화합물

시약·촉매·용매 1

HCID 962Water용매

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온도
80 °C

실험 절차

1-(6-Amino-3,5-difluoropyridin-2-yl)-8-bromo-6-fluoro-7-(3-isopropylaminoazetidin-1-yl)-4-oxo-1,4-dihydroquinolin-3-carboxylic acid (132 mg) and maleic acid (58 mg) were added to ethanol (3 mL), and the mixture was heated at 80° C. Water was gradually added to the mixture until the compounds were completely dissolved. After the solution had been left to cool, the formed solid was collected through filtration, to thereby yield 102 mg of the title compound.

후처리

  1. dissolutionwere completely dissolved
  2. waitAfter the solution had been left
  3. temperatureto cool
  4. filtrationthe formed solid was collected through filtration

출처 및 근거

ORD 기록
ord-31725629c7b4403c8215b20a560bee53
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07713997B2

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