(1-Phenyl-cyclohexyl)-carbamic acid benzyl ester → 1-Phenylcyclohexylamine

HRID 2235199노트

반응식

HRID 2235199 반응식
C(OC(=O)[NH:10][C:11]1([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]1)C1C=CC=CC=1>CO.[Pd]>[C:17]1([C:11]2([NH2:10])[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

4

반응물 1

HCID 59299316(1-Phenyl-cyclohexyl)-carbamic acid benzyl ester

생성물 1

HCID 318621-Phenylcyclohexylamine수율 90.4%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

Dissolve (1-phenyl-cyclohexyl)-carbamic acid benzyl ester (Preparation 27) (2.87 g, 9.26 mmol) in MeOH (100 mL). Exchange air with nitrogen for three times and then add Pd—C (0.5 g, 10%). Exchange the nitrogen with H2 for three times. Stir the reaction mixture under H2 for over night then remove the Pd—C by filtration. Remove the solvent under reduced pressure to give 1.468 g (90%) of the crude title compound as a colorless oil.

후처리

  1. customthen remove the Pd—C
  2. filtrationby filtration
  3. customRemove the solvent under reduced pressure

출처 및 근거

ORD 기록
ord-658ad1920c5349a7aedaee767557cf7c
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07713979B2

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