Potassium Carbonate → HCID 59300816, 화합물

HRID 2235377

반응식

HRID 2235377 반응식
[CH3:1][C:2]1([CH3:19])[C:10]2[C:5](=[CH:6][C:7]([N+:15]([O-:17])=[O:16])=[C:8]([NH:11]C(=O)C)[CH:9]=2)[NH:4][C:3]1=[O:18].Cl[CH:21]([CH3:24])[C:22]#[CH:23].C([O-])([O-])=O.[K+].[K+].C1CCN2C(=NCCC2)CC1>CO>[NH2:11][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][C:7]=1[N+:15]([O-:17])=[O:16])[N:4]([CH:22]([CH3:23])[C:21]#[CH:24])[C:3](=[O:18])[C:2]2([CH3:1])[CH3:19]

참가 물질

6

반응물 4

HCID 11430Potassium CarbonateHCID 304433-Chloro-1-butyneHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 23092658N-(3,3-Dimethyl-6-nitro-2-oxo-2,3-dihydro-1H-indol-5-yl)acetamide

생성물 1

HCID 59300816HCID 59300816, 화합물수율 50.1%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Analogously to general procedure (I) N-(3,3-dimethyl-6-nitro-2-oxo-2,3-dihydro-1H-indol-5-yl)-acetamide (2.5 g) is alkylated using (rac)-3-chloro-but-1-yne (0.86 g; 9.5 mmol) and K2CO3 (3.28 g; 23.7 mmol) at 50° C. for 14 days. After aqueous work-up the crude material (1.51 g) is de-acetylated in MeOH (40 ml) using DBU (0.3 ml) at reflux. After aqueous work-up (rac)-5-amino-3,3-dimethyl-1-(1-methyl-prop-2-ynyl)-6-nitro-1,3-dihydro-indol-2-one (1,3 g) is obtained and used without further purification.

후처리

  1. customat 50° C.
  2. customfor 14 days
  3. temperatureat reflux

출처 및 근거

ORD 기록
ord-60c0f55c6f6243309cf33691b10c6972
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07714010B2

연결된 노트

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