Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → [6-(Hydroxymethyl)pyridin-3-yl]methanol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Hydride | HCID 166653 | — |
| 반응물 | 2,5-Di(acetoxymethyl)pyridine | HCID 20263986 | — |
| 반응물 | Aluminium lithium hydride | HCID 21226445 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | [6-(Hydroxymethyl)pyridin-3-yl]methanol | HCID 820251 | — |
반응 단계
2,5-Di(acetoxymethyl)pyridine (0.05 mole) is reduced with lithium aluminum hydride (0.025 mole) in tetrahydrofuran (50 ml.) at 0° C. with stirring. After one hour, water is added to decompose excess hydride, and the mixture is concentrated to dryness. The residue is extracted with hot isopropanol (2×60 ml.) and the extract is concentrated to dryness to give 2,5-di(hydroxymethyl)pyridine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04355034 |
| 출처 데이터셋 | uspto-grants-1982_10 |
| ORD ID | ord-5cdfdb96128d45b2bb3d6281723a2237 |
| 출처 메모 | uspto-grants-1982_10 |