Water → [6-(Hydroxymethyl)pyridin-3-yl]methanol

HRID 223539

반응식

HRID 223539 반응식
C([O:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][O:13]C(=O)C)=[CH:8][N:7]=1)(=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-].O.[H-]>O1CCCC1>[OH:4][CH2:5][C:6]1[CH:11]=[CH:10][C:9]([CH2:12][OH:13])=[CH:8][N:7]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 166653HydrideHCID 202639862,5-Di(acetoxymethyl)pyridineHCID 21226445Aluminium lithium hydride

생성물 1

HCID 820251[6-(Hydroxymethyl)pyridin-3-yl]methanol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

2,5-Di(acetoxymethyl)pyridine (0.05 mole) is reduced with lithium aluminum hydride (0.025 mole) in tetrahydrofuran (50 ml.) at 0° C. with stirring. After one hour, water is added to decompose excess hydride, and the mixture is concentrated to dryness. The residue is extracted with hot isopropanol (2×60 ml.) and the extract is concentrated to dryness to give 2,5-di(hydroxymethyl)pyridine.

후처리

  1. concentrationthe mixture is concentrated to dryness
  2. extractionThe residue is extracted with hot isopropanol (2×60 ml.)
  3. concentrationthe extract is concentrated to dryness

출처 및 근거

ORD 기록
ord-5cdfdb96128d45b2bb3d6281723a2237
출처 데이터셋
uspto-grants-1982_10
특허 번호
US04355034

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