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Isopropyl iodide → 5-Isopropylamino-3,3-dimethyl-6-nitro-1-pentyl-1,3-dihydro-indol-2-one

HRID 2235458
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인쇄 미리보기

반응식

HRID 2235458 반응식
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[N:7]([CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[C:6](=[O:19])[C:5]2([CH3:21])[CH3:20].I[CH:23]([CH3:25])[CH3:24].CC([O-])(C)C.[K+].C(Cl)Cl.CO>CN(C)C=O>[CH:23]([NH:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][C:10]=1[N+:11]([O-:13])=[O:12])[N:7]([CH2:14][CH2:15][CH2:16][CH2:17][CH3:18])[C:6](=[O:19])[C:5]2([CH3:20])[CH3:21])([CH3:25])[CH3:24]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 4

HCID 6362Isopropyl iodideHCID 178027445-Amino-3,3-dimethyl-6-nitro-1-pentyl-1,3-dihydro-indol-2-oneHCID 21226129Dichloromethane methanolHCID 23665647Potassium tert-butoxide

생성물 1

HCID 674274925-Isopropylamino-3,3-dimethyl-6-nitro-1-pentyl-1,3-dihydro-indol-2-one수율 35%

시약·촉매·용매 1

HCID 6228
Dimethylformamide
용매

실험 절차

A8 (0.5 g) is alkylated using 2-iodopropane (0.5 ml; 5 mmol) and KOtBu (561 mg; 5 mmol) in N,N-dimethylformamide (7 ml) for 20 h at RT. After aqueous work-up and flash chromatography on silica gel eluting with CH2Cl2/MeOH (98:2) the compound (200 mg) is obtained.

후처리

  1. customfor 20 h
  2. customat RT

출처 및 근거

ORD 기록
ord-5f6103573be5451189778331726472e7
출처 데이터셋
uspto-grants-2010_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07714010B2

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