5-Isopropylamino-3,3-dimethyl-6-nitro-1-pentyl-1,3-dihydro-indol-2-one → 6-Amino-5-isopropylamino-3,3-dimethyl-1-pentyl-1,3-dihydro-indol-2-one

HRID 2235459노트

반응식

HRID 2235459 반응식
[CH:1]([NH:4][C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][C:13]=1[N+:14]([O-])=O)[N:10]([CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])[C:9](=[O:22])[C:8]2([CH3:24])[CH3:23])([CH3:3])[CH3:2]>CN(C)C=O.[Pd]>[NH2:14][C:13]1[CH:12]=[C:11]2[C:7]([C:8]([CH3:24])([CH3:23])[C:9](=[O:22])[N:10]2[CH2:17][CH2:18][CH2:19][CH2:20][CH3:21])=[CH:6][C:5]=1[NH:4][CH:1]([CH3:2])[CH3:3]

참가 물질

4

반응물 1

HCID 674274925-Isopropylamino-3,3-dimethyl-6-nitro-1-pentyl-1,3-dihydro-indol-2-one

생성물 1

HCID 674272526-Amino-5-isopropylamino-3,3-dimethyl-1-pentyl-1,3-dihydro-indol-2-one수율 98.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 6228Dimethylformamide용매

실험 절차

5-Isopropylamino-3,3-dimethyl-6-nitro-1-pentyl-1,3-dihydro-indol-2-one (200 mg) is dissolved in N,N-dimethylformamide (10 ml) and hydrogenated at RT at 3 bar for 12 h using Pd/C (10%; 0.1 g) as catalyst. After completion of the reaction the mixture is filtered and evaporated to give the compound (180 mg).

후처리

  1. customAfter completion of the reaction the mixture
  2. filtrationis filtered
  3. customevaporated

출처 및 근거

ORD 기록
ord-683e9cf6a17f4091985f8279a337732a
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07714010B2

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