Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetone → 8-{3-[4-(bis(4-fluorophenyl)hydroxymethyl)-1-piperidinyl]propoxy}-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetone | HCID 180 | — |
| 반응물 | Fumarate | HCID 5460307 | — |
| 반응물 | Bis(4-fluorophenyl)(piperidin-4-yl)methanol | HCID 11208889 | — |
| 반응물 | 8-(3-chloropropoxy)-2,3-dihydro-7-methoxycyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927690 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | tert-Butyl methyl ether | HCID 15413 | — |
| 생성물 | 8-{3-[4-(bis(4-fluorophenyl)hydroxymethyl)-1-piperidinyl]propoxy}-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927669 | 67% |
반응 단계
Method B (38 h at 60° C.); starting materials: 8-(3-chloropropoxy)-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one (example 83) and 4-[bis(4-fluorophenyl)hydroxy-methyl]piperidine; yield 67%; fusion point 91° C. (decomposes; from acetone and TBME). Fumarate (×0.5 C4H4O4): method E; yield 70%; fusion point 191° C. (decomposes; from water).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05428038 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-bb603f9d9f244b9cb7303716b685f5eb |
| 출처 메모 | uspto-grants-1995_06 |