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Dipropylamine → 7-((Dipropylamino)methyl)-N-mesityl-1,3-benzothiazol-2-amine

HRID 2235525
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HRID 2235525 반응식
Br[CH2:2][C:3]1[C:11]2[S:10][C:9]([NH:12][C:13]3[C:18]([CH3:19])=[CH:17][C:16]([CH3:20])=[CH:15][C:14]=3[CH3:21])=[N:8][C:7]=2[CH:6]=[CH:5][CH:4]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:28]([NH:31][CH2:32][CH2:33][CH3:34])[CH2:29][CH3:30]>C(#N)C.ClCCl>[CH2:28]([N:31]([CH2:2][C:3]1[C:11]2[S:10][C:9]([NH:12][C:13]3[C:18]([CH3:19])=[CH:17][C:16]([CH3:20])=[CH:15][C:14]=3[CH3:21])=[N:8][C:7]=2[CH:6]=[CH:5][CH:4]=1)[CH2:32][CH2:33][CH3:34])[CH2:29][CH3:30]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 8902DipropylamineHCID 11430Potassium CarbonateHCID 860491237-(Bromomethyl)-N-mesityl-1,3-benzothiazol-2-amine

생성물 1

HCID 588965287-((Dipropylamino)methyl)-N-mesityl-1,3-benzothiazol-2-amine수율 59%

시약·촉매·용매 2

HCID 6342Acetonitrile용매
HCID 6344
Dichloromethane
용매
2회

실험 절차

To 0.045 g (0.12 mmol) of 7-(bromomethyl)-N-mesityl-1,3-benzothiazol-2-amine in 0.5 mL of acetonitrile and 2 mL of dichloromethane was added 0.086 g (0.62 mmol) of potassium carbonate and 85 μl, (0.62 mmol) of dipropylamine. The reaction was stirred for 40 min, diluted with dichloromethane and filtered. The filtrate was concentrated and purified by flash chromatography eluting with a 25% ethyl acetate/hexanes mixture to give 0.027 g (57%) of the title compound as a light yellow powder.

후처리

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated
  3. custompurified by flash chromatography
  4. washeluting with a 25% ethyl acetate/hexanes mixture

출처 및 근거

ORD 기록
ord-870ef0b6fab14944bf7c52fd7f376179
출처 데이터셋
uspto-grants-2010_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07714009B2

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