Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → 8-{3-[4-(2-fluorophenyl)-1-piperazinyl]propoxy}-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | 1-(2-Fluorophenyl)piperazine | HCID 70529 | — |
| 반응물 | Fumarate | HCID 5460307 | — |
| 반응물 | 8-(3-chloropropoxy)-2,3-dihydro-7-methoxycyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927690 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 8-{3-[4-(2-fluorophenyl)-1-piperazinyl]propoxy}-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one | HCID 19927651 | 59% |
반응 단계
Method B (50 h at 60° C.); starting materials: 8-(3-chloropropoxy)-2,3-dihydro-7-methoxy-cyclopenta[c][1]benzopyran-4(1H)-one (example 83) and 1-(2-fluorophenyl)piperazine; yield 59%; fusion point 148°-150° C. (from ethanol). Fumarate (×H2O): method E; yield 78%; the fusion point being 205°-210° C. (from water).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05428038 |
| 출처 데이터셋 | uspto-grants-1995_06 |
| ORD ID | ord-ffb7d8f8438241a2a755d5adb4e42c60 |
| 출처 메모 | uspto-grants-1995_06 |