Hydrazine → 2-(4-Fluorophenyl)-4-hydroxy-2-methoxybutyric acid hydrazide

HRID 2235748노트

반응식

HRID 2235748 반응식
[NH2:1][NH2:2].[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2([O:16][CH3:17])[CH2:14][CH2:13][O:12][C:11]2=[O:15])=[CH:6][CH:5]=1>C(O)C>[F:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]([O:16][CH3:17])([CH2:14][CH2:13][OH:12])[C:11]([NH:1][NH2:2])=[O:15])=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 9321HydrazineHCID 670671553-(4-Fluorophenyl)-3-methoxydihydrofuran-2-one

생성물 1

HCID 670673452-(4-Fluorophenyl)-4-hydroxy-2-methoxybutyric acid hydrazide수율 96.2%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

A solution of hydrazine (29 mg) in ethanol (0.5 mL) was added to a solution of 3-(4-fluorophenyl)-3-methoxydihydrofuran-2-one (37 mg) in ethanol (1.2 mL), and the reaction solution was stirred at room temperature for 2.5 hours. The reaction solution was concentrated under reduced pressure to obtain 41 mg of the title compound. The property values of the compound are as follows.

후처리

  1. concentrationThe reaction solution was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-d266701497504887bd0ddaf44430526e
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07713993B2

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