Phenylhydrazine hydrochloride → 2,3,4,5-Tetrahydro-1H-pyrido[4,3-b]indole hydrochloride
반응식
[ClH:1].O.[NH:3]1[CH2:8][CH2:7][C:6](=O)[CH2:5][CH2:4]1.Cl.[C:11]1([NH:17]N)[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(O)C>[ClH:1].[CH2:4]1[C:5]2[C:16]3[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=3[NH:17][C:6]=2[CH2:7][CH2:8][NH:3]1참가 물질
4
실험 절차
4-Piperidone monohydrate hydrochloride (10 g, 65.1 mmol) and phenylhydrazine hydrochloride (9.4 g, 65.1 mmol) are suspended in ethanol (200 ml) and stirred at reflux overnight. The resulting solid is filtered off and washed with diethyl ether to afford pure sub-title compound (11.9 g) in 88% yield. tR (LC-2) 0.89; ESI-MS (positive ion): m/z 173.34 [M+H]+ (calcd 172.23 for C11H12N2).
후처리
- temperatureat reflux overnight
- filtrationThe resulting solid is filtered off
- washwashed with diethyl ether
출처 및 근거
- ORD 기록
- ord-96e7a1b6446b460c818ddf17c8a17d1e
- 출처 데이터셋
- uspto-grants-2010_05
- 특허 번호
- US07714132B2
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