Piperonylamine → 8-Methoxy-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole
반응식
Cl.O.[NH:3]1[CH2:8][CH2:7][C:6](=O)[CH2:5][CH2:4]1.Cl.[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]([NH:19]N)=[CH:15][CH:14]=1>C(O)C>[CH3:11][O:12][C:13]1[CH:18]=[CH:17][C:16]2[NH:19][C:6]3[CH2:5][CH2:4][NH:3][CH2:8][C:7]=3[C:15]=2[CH:14]=1참가 물질
4
실험 절차
A suspension of 4-piperidone monohydrate hydrochloride (1.0 g, 6.5 mmol) and 4-methoxyphenylhydrazine hydrochloride (1.14 g, 6.5 mmol) in ethanol (17 ml) is kept stirring at reflux overnight. The resulting solid is filtered off and washed with diethyl ether to afford crude sub-title compound, which is used without further purification: tR (LC-1) 0.38; ESI-MS (positive ion): m/z 203.19 [M+H]+ (calcd 202.25 for C12H14N2O).
후처리
- temperatureat reflux overnight
- filtrationThe resulting solid is filtered off
- washwashed with diethyl ether
출처 및 근거
- ORD 기록
- ord-20d12c8a9c654fc2ac752bec5935fac4
- 출처 데이터셋
- uspto-grants-2010_05
- 특허 번호
- US07714132B2
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