Pyridine → 1H-Indole-6-carbaldehyde O-methyl-oxime

HRID 2236430

반응식

HRID 2236430 반응식
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH:10]=O)[CH:8]=2)[CH:3]=[CH:2]1.N1C=CC=CC=1.Cl.[O:19]([NH2:21])[CH3:20]>O>[CH3:20][O:19][N:21]=[CH:10][C:7]1[CH:8]=[C:9]2[C:4]([CH:3]=[CH:2][NH:1]2)=[CH:5][CH:6]=1

참가 물질

5

반응물 3

HCID 1049PyridineHCID 521874O-Methylhydroxylamine hydrochlorideHCID 27734351H-Indole-6-carboxaldehyde

생성물 1

HCID 722508601H-Indole-6-carbaldehyde O-methyl-oxime수율 82.6%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

An amount of 1H-Indole-6-carbaldehyde (50 mg, 0.34 mmol) is added to pyridine (2.0 ml) at room temperature, followed by addition of methoxylamine hydrogen chloride (31.6 mg, 0.38 mmol). The mixture is stirred at ambient temperature for 24 h, and 10 mL of water is added. After the solvents were evaporated, the residue is dissolved 10 mL of anhydrous ether, washed successively with 10 mL of aqueous sodium bicarbonate, 10 mL of sodium bisulfite, and 10 mL of brine. Dried over magnesium sulfate, evaporated to give a white solid (49 mg, 0.281 mmol). MS (ESI) m/z 176.3 (M+1)

후처리

  1. customAfter the solvents were evaporated
  2. dissolutionthe residue is dissolved 10 mL of anhydrous ether
  3. washwashed successively with 10 mL of aqueous sodium bicarbonate, 10 mL of sodium bisulfite, and 10 mL of brine
  4. dry with materialDried over magnesium sulfate
  5. customevaporated

출처 및 근거

ORD 기록
ord-9755bd7b0d8e47f39496ab019f24d438
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07713994B2

연결된 노트

불러오는 중…