Thionyl Chloride → 4-Chloromethyl-2-methoxy-biphenyl
반응식
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH2:9]O)[CH:6]=[CH:5][C:4]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.O=S(Cl)[Cl:19]>C(Cl)Cl>[Cl:19][CH2:9][C:7]1[CH:6]=[CH:5][C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=[C:3]([O:2][CH3:1])[CH:8]=1참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
(2-Methoxy-biphenyl-4-yl)-methanol (170 mg, 0.79 mmol) [PCT Int. Appl. 1999, WO 9955726 A1 19991104] is dissolved in CH2Cl2 (2 mL) and cooled to 0° C. SOCl2 (1 mL) is then added dropwise. The mixture is then allowed to stir till no starting material left. The volatiles were then removed and the crude product is employed in the next step directly.
후처리
- waitleft
- customThe volatiles were then removed
출처 및 근거
- ORD 기록
- ord-10d5fa22698049f589b3170cda6d21d4
- 출처 데이터셋
- uspto-grants-2010_05
- 특허 번호
- US07713994B2
반응 노트
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