Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Chloroform → Methyl 4-butyl-3-methoxybenzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Chloroform | HCID 6212 | — |
| 반응물 | Tris(1,1-dimethylethyl)phosphine | HCID 83681 | — |
| 반응물 | Methyl 4-iodo-3-methoxybenzoate | HCID 11243290 | — |
| 반응물 | HCID 178448257 | HCID 178448257 | — |
| 촉매 | Bis(dibenzylideneacetone)palladium | HCID 9811564 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | Methyl 4-butyl-3-methoxybenzoate | HCID 59300121 | — |
반응 단계
4-Iodo-3-methoxy-benzoic acid methyl ester (292 mg, 1 mmol) and Pd2(dba)3.CHCl3 (25 mg, 0.025 mmol) and P(tBu)3 (0.25 mL, 10% in hexane, 0.08 mmol) and n-BuZnBr (4 mL, 0.5 M in THF, 2.0 mmol) is mixed in N,N-dimethylformamide (4 mL) together and degassed. After stirring at room temperature for 1 hour, analysis of TLC suggested no starting material left and reaction is stopped. Et2O and H2O were then added and the ether layer is washed with water and dried. After the removal of ether, the residue is directly used in the next step after pass through a short column.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07713994B2 |
| 출처 데이터셋 | uspto-grants-2010_05 |
| ORD ID | ord-234feb9bdb2e403eb3608fe74aab6c61 |
| 출처 메모 | uspto-grants-2010_05 |