1-Butyl-4-chloromethyl-2-methoxy-benzene → 4-Azidomethyl-1-butyl-2-methoxy-benzene

반응식

[N:1]([CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2C=C[CH:14]=[CH:13][CH:12]=2)=[C:7]([O:17][CH3:18])[CH:6]=1)=[N+:2]=[N-:3].C(C1C=CC(CCl)=CC=1OC)CCC>>[N:1]([CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][CH2:13][CH3:14])=[C:7]([O:17][CH3:18])[CH:6]=1)=[N+:2]=[N-:3]

참가 물질

반응물 2

HCID 593002161-Butyl-4-chloromethyl-2-methoxy-benzene

HCID 593002734-Azidomethyl-2-methoxy-biphenyl

생성물 1

HCID 593001534-Azidomethyl-1-butyl-2-methoxy-benzene수율 36%

실험 절차

Following the same procedure for the preparation of 4-Azidomethyl-2-methoxy-biphenyl, the title compound is prepared from 1-Butyl-4-chloromethyl-2-methoxy-benzene (crude material from the previous step) in 36% yield (overall yield for 4 steps).

후처리

customin 36% yield (overall yield for 4 steps)

출처 및 근거

ORD 기록: ord-305d1ae7fdbf442182c910cbf7f01e89
출처 데이터셋: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07713994B2

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