Aluminium lithium hydride → (4'-Fluoro-2-methoxy-biphenyl-4-yl)-methanol
반응식
C[O:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[C:7]([O:18][CH3:19])[CH:6]=1)=O.[H-].[H-].[H-].[H-].[Li+].[Al+3]>CCOCC>[F:17][C:14]1[CH:13]=[CH:12][C:11]([C:8]2[CH:9]=[CH:10][C:5]([CH2:3][OH:2])=[CH:6][C:7]=2[O:18][CH3:19])=[CH:16][CH:15]=1참가 물질
4
실험 절차
4′-Fluoro-2-methoxy-biphenyl-4-carboxylic acid methyl ester (220 mg, 0.85 mmol) is allowed to dissolve in ether and cooled. LiAlH4 (80 mg, 2.12 mmol) is then added and the suspension is then stirred overnight. After aqueous work up, the alcohol is isolated and used directly in the next step.
후처리
- temperaturecooled
출처 및 근거
- ORD 기록
- ord-70584e60d60644e79344b038ccb41efa
- 출처 데이터셋
- uspto-grants-2010_05
- 특허 번호
- US07713994B2
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