Ammonium Hydroxide → 4-Chloro-3-hydroxybenzamide

HRID 2236521노트

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HRID 2236521 반응식
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](Cl)=[O:7])=[CH:4][C:3]=1[OH:11].[OH-].[NH4+:13]>O>[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:13])=[O:7])=[CH:4][C:3]=1[OH:11]

참가 물질

4

반응물 2

HCID 14923Ammonium HydroxideHCID 754648184-Chloro-3-hydroxybenzoyl chloride

생성물 1

HCID 451201374-Chloro-3-hydroxybenzamide수율 86%

시약·촉매·용매 1

HCID 962Water용매

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온도
0 °C

실험 절차

4-Chloro-3-hydroxy-benzoyl chloride is cooled to 0° C. and 20 ml of ammonium hydroxide were added within 5 minutes. The mixture is allowed to stir at 0° C. for 30 minutes, then at room temperature for additional 30 minutes. 30 ml of water is added to the mixture and the white precipitate is filtered, the pH of the water layer is adjusted to 3, followed by extraction with ethyl acetate, dried over MgSO4 to give 4-chloro-3-hydroxy-benzamide as a white solid 850 mg (86% yield).

후처리

  1. waitat room temperature for additional 30 minutes
  2. filtrationthe white precipitate is filtered
  3. extractionfollowed by extraction with ethyl acetate
  4. dry with materialdried over MgSO4

출처 및 근거

ORD 기록
ord-648c1bf9d84b402cbd7b32f4c8adb7a6
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07713994B2

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