Sodium Azide → 2-Azidomethyl-5-propoxy-pyridin-4-ol

HRID 2236539노트

반응식

HRID 2236539 반응식
[N-:1]=[N+:2]=[N-:3].[Na+].Cl[CH2:6][C:7]1[CH:12]=[C:11]([OH:13])[C:10]([O:14][CH2:15][CH2:16][CH3:17])=[CH:9][N:8]=1>CN(C)C=O>[N:1]([CH2:6][C:7]1[CH:12]=[C:11]([OH:13])[C:10]([O:14][CH2:15][CH2:16][CH3:17])=[CH:9][N:8]=1)=[N+:2]=[N-:3]

참가 물질

4

반응물 2

HCID 33557Sodium AzideHCID 178458779HCID 178458779, 화합물

생성물 1

HCID 1784587892-Azidomethyl-5-propoxy-pyridin-4-ol

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a suspension of sodium azide (2.82 g, 43.3 mmole) in 30 mL of N,N-dimethylformamide is added 2-chloromethyl-5-propoxy-pyridin-4-ol (8.74 g, 43.3 mmole). This is stirred for overnight at ambient temperature then quenched into ice water. The solid formed is filtered, washed with cold water and dried to give an off white solid, 5.74 g, (63%); MS (ES+): m/z 209.3 (M+H).

후처리

  1. customthen quenched into ice water
  2. customThe solid formed
  3. filtrationis filtered
  4. washwashed with cold water
  5. customdried
  6. customto give an off white solid, 5.74 g, (63%)

출처 및 근거

ORD 기록
ord-67ed3b4eb1544676b1725ced3ff6a336
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07713994B2

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