Dimethylformamide → HCID 178487208, 화합물

HRID 2236611노트

반응식

HRID 2236611 반응식
Cl.[NH2:2][CH2:3][C:4]1[CH:5]=[CH:6][C:7]([O:11][CH3:12])=[C:8]([OH:10])[CH:9]=1.CN(C)C=O.C(N(CC)CC)C.[CH3:25][O:26][C:27]1[CH:28]=[C:29]2[C:34](=[CH:35][CH:36]=1)[C:33](=[O:37])[NH:32][C:31](=[O:38])/[C:30]/2=[CH:39]/OC>CCOCC>[OH:10][C:8]1[CH:9]=[C:4]([CH:5]=[CH:6][C:7]=1[O:11][CH3:12])[CH2:3][NH:2][CH:39]=[C:30]1[C:29]2[C:34](=[CH:35][CH:36]=[C:27]([O:26][CH3:25])[CH:28]=2)[C:33](=[O:37])[NH:32][C:31]1=[O:38]

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 162176463-Hydroxy-4-methoxybenzylamine hydrochlorideHCID 59299827(4E)-6-methoxy-4-methoxymethylene-4H-isoquinoline-1,3-dione

생성물 1

HCID 178487208HCID 178487208, 화합물

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

A mixture of 5-aminomethyl-2-methoxy-phenol hydrochloride (145 mg, 0.50 mmole), 4 mL of N,N-dimethylformamide and triethylamine (75 □L, 0.54 mmole) is stirred for 15 minutes. Then (4E)-6-methoxy-4-methoxymethylene-4H-isoquinoline-1,3-dione (117 mg, 0.50 mmole) is added and the reaction mixture stirred for one hour. The reaction mixture is diluted with ether, filtered washed with water, washed with ether and dried to give an light beige solid, 161 mg, (91%), mp 240-2° C. dec; MS (ESI): m/z 355.2 (M−H).

후처리

  1. stirringthe reaction mixture stirred for one hour
  2. filtrationfiltered
  3. washwashed with water
  4. washwashed with ether
  5. customdried
  6. customto give an light beige solid, 161 mg, (91%), mp 240-2° C. dec

출처 및 근거

ORD 기록
ord-449c492213ae44eaa57f91c39f9fc1d7
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07713994B2

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