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Water → (4Z)-6-bromo-4-[[[3-hydroxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]methylamino]methylidene]isoquinoline-1,3-dione

HRID 2236624
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HRID 2236624 반응식
[NH2:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([O:10][CH2:11][CH2:12][N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)=[C:7]([OH:9])[CH:8]=1.C(N(CC)CC)C.[Br:25][C:26]1[CH:27]=[C:28]2[C:33](=[CH:34][CH:35]=1)[C:32](=[O:36])[NH:31][C:30](=[O:37])/[C:29]/2=[CH:38]/OC.O>CN(C)C=O>[Br:25][C:26]1[CH:27]=[C:28]2[C:33](=[CH:34][CH:35]=1)[C:32](=[O:36])[NH:31][C:30](=[O:37])/[C:29]/2=[CH:38]\[NH:1][CH2:2][C:3]1[CH:4]=[CH:5][C:6]([O:10][CH2:11][CH2:12][N:13]2[CH2:17][CH2:16][CH2:15][CH2:14]2)=[C:7]([OH:9])[CH:8]=1
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참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 592998755-Aminomethyl-2-(2-pyrrolidin-1-yl-ethoxy)-phenolHCID 68692760(E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione

생성물 1

HCID 178518273(4Z)-6-bromo-4-[[[3-hydroxy-4-(2-pyrrolidin-1-ylethoxy)phenyl]methylamino]methylidene]isoquinoline-1,3-dione수율 66.6%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

An amount of 33.5 mg (0.142 mmol) of 5-Aminomethyl-2-(2-pyrrolidin-1-yl-ethoxy)-phenol, is dissolved in N,N-dimethylformamide (2 ML). 30 μl (0.213 mmol) of triethylamine is added followed by 20 mg (0.071 mmol) of (4E)-6-bromo-4-(methoxymethylene)isoquinoline-1,3(2H,4H)-dione. After the mixture is stirred at room temperature for 30 min, water (2 mL) is added and the reaction mixture is stirred for 60 min. The precipitate is filtered and washed several times with anhydrous ether. The crude solid is then purified by high performance liquid chromatography to give 23 mg of a yellow solid. MS (ESI) m/z 486.3 (M+1).

후처리

  1. stirringthe reaction mixture is stirred for 60 min
  2. filtrationThe precipitate is filtered
  3. washwashed several times with anhydrous ether
  4. customThe crude solid is then purified by high performance liquid chromatography

출처 및 근거

ORD 기록
ord-2586240e61844c80a7de342dfc656ae6
출처 데이터셋
uspto-grants-2010_05
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07713994B2

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