Chloride → HCID 178460087, 화합물

HRID 2236826노트

반응식

HRID 2236826 반응식
[NH2:1][C:2]1[C:3]([OH:24])=[CH:4][C:5]([CH2:8][NH:9][CH:10]=[C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([I:21])[CH:19]=3)[C:14](=[O:22])[NH:13][C:12]2=[O:23])=[N:6][CH:7]=1.[Cl-]>CC(N(C)C)=O>[OH:24][C:3]1[CH:4]=[C:5]([CH2:8][NH:9][CH:10]=[C:11]2[C:20]3[C:15](=[CH:16][CH:17]=[C:18]([I:21])[CH:19]=3)[C:14](=[O:22])[NH:13][C:12]2=[O:23])[N:6]=[CH:7][C:2]=1[NH:1][C:14](=[O:22])[CH:15]=[CH2:16]

참가 물질

4

반응물 2

HCID 312ChlorideHCID 1785080254-[[(5-amino-4-oxo-1H-pyridin-2-yl)methylamino]methylidene]-6-iodoisoquinoline-1,3-dione

생성물 1

HCID 178460087HCID 178460087, 화합물

시약·촉매·용매 1

HCID 31374Dimethylacetamide용매

실험 절차

A mixture of 4-{[(5-Amino-4-hydroxy-pyridin-2-ylmethyl)-amino]-methylene}-6-iodo-4H-isoquinoline-1,3-dione (334 mg, 0.766 mmole), 20 mL of dimethylacetamide is stirred, acryoyl chloride (651 uL, 7.66 mmole) is added and the reaction mixture stirred for one hour. The reaction mixture is evaporated to dryness, stirred overnight with a saturated aqueous sodium bicarbonate solution, filtered, washed well with water, and dried to give a green solid, 98 mg, (27%); MS (ES−): m/z 489 (M−H).

후처리

  1. stirringthe reaction mixture stirred for one hour
  2. customThe reaction mixture is evaporated to dryness
  3. stirringstirred overnight with a saturated aqueous sodium bicarbonate solution
  4. filtrationfiltered
  5. washwashed well with water
  6. customdried
  7. customto give a green solid, 98 mg, (27%)

출처 및 근거

ORD 기록
ord-8f9d65a4b37c4612b71df8cb41a14ccc
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07713994B2

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