3-Hydroxy-4-phenylbenzylamine → HCID 178518360, 화합물

HRID 2236862노트

반응식

HRID 2236862 반응식
[NH2:1][CH2:2][C:3]1[CH:4]=[C:5]([OH:15])[C:6]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)=[CH:7][CH:8]=1.[I:16][C:17]1[CH:18]=[C:19]2[C:24](=[CH:25][CH:26]=1)[C:23](=[O:27])[NH:22][C:21](=[O:28])[C:20]2=[CH:29]OC>CN(C)C=O>[OH:15][C:5]1[CH:4]=[C:3]([CH2:2][NH:1][CH:29]=[C:20]2[C:19]3[C:24](=[CH:25][CH:26]=[C:17]([I:16])[CH:18]=3)[C:23](=[O:27])[NH:22][C:21]2=[O:28])[CH:8]=[CH:7][C:6]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1

참가 물질

4

반응물 2

HCID 231438563-Hydroxy-4-phenylbenzylamineHCID 686910194-methoxymethylene-6-iodo-4H-isoquinoline-1,3-dione

생성물 1

HCID 178518360HCID 178518360, 화합물수율 89.5%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

4-Aminomethyl-biphenyl-2-ol (80 mg, 0.4 mmol) and 6-iodo-4-methoxymethylene-4H-isoquinoline-1,3-dione (110 mg, 0.34 mmol) is stirred in N,N-dimethylformamide (5 mL). After which N,N-dimethylformamide is removed under vacuum and the residue is triturated with MeOH. The precipitate thus formed is collected and washed with MeOH and dried to provide the title compound (151 mg, 89%). MS (ESI): 495.1 (M−1)−1.

후처리

  1. customAfter which N,N-dimethylformamide is removed under vacuum
  2. customthe residue is triturated with MeOH
  3. customThe precipitate thus formed
  4. customis collected
  5. washwashed with MeOH
  6. customdried

출처 및 근거

ORD 기록
ord-dae6d350212d43ed91dae3eabd769649
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07713994B2

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