Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Imidazole → 7-{2-Butyl-4-[4-(4-methoxy-phenoxy)-phenyl]-imidazol-1-yl}-1,2,3,4-tetrahydro-isoquinoline hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Imidazole | HCID 795 | — |
| 반응물 | Urea | HCID 1176 | — |
| 반응물 | Valeryl chloride | HCID 61186 | — |
| 반응물 | Carbonyl bromide | HCID 79057 | — |
| 반응물 | 1-(4-(4-Methoxyphenoxy)phenyl)ethan-1-one | HCID 2777253 | — |
| 반응물 | tert-Butyl 7-amino-3,4-dihydroisoquinoline-2(1H)-carboxylate | HCID 22061016 | — |
| 생성물 | 7-{2-Butyl-4-[4-(4-methoxy-phenoxy)-phenyl]-imidazol-1-yl}-1,2,3,4-tetrahydro-isoquinoline hydrochloride | HCID 66977535 | — |
반응 단계
1-[4-(4-methoxyphenoxy)phenyl]ethan-1-one (1 mmol) was brominated by General Procedure R1. The bromo ketone was condensed with 7-amino-2-Boc-1,2,3,4-tetrahydroisoquinoline following general procedure R2. The aminoketone intermediate was treated with n-pentanoyl chloride accoding to General Procedure R3. The product amide was then subjected to imidazole formation employing general procedure R4. The BOC group of the product was removed employing general procedure T1 to afford 7-{2-butyl-4-[4-(4-methoxy-phenoxy)-phenyl]-imidazol-1-yl}-1,2,3,4-tetrahydro-isoquinoline hydrochloride (yield 135 mg)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07714013B2 |
| 출처 데이터셋 | uspto-grants-2010_05 |
| ORD ID | ord-3f22503a2e4643e79fa627d0fb889e26 |
| 출처 메모 | uspto-grants-2010_05 |