4-Chlorophenylboronic acid → 1-(4-chlorophenyl)-3-(3-chloropropyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide

반응식

[Cl:1][CH2:2][CH2:3][CH2:4][N:5]1[CH2:10][C:9]2[CH:11]=[CH:12][CH:13]=[CH:14][C:8]=2[NH:7][S:6]1(=[O:16])=[O:15].[Cl:17][C:18]1[CH:23]=[CH:22][C:21](B(O)O)=[CH:20][CH:19]=1>>[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([N:7]2[C:8]3[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=3[CH2:10][N:5]([CH2:4][CH2:3][CH2:2][Cl:1])[S:6]2(=[O:16])=[O:15])=[CH:20][CH:19]=1

참가 물질

반응물 2

HCID 742994-Chlorophenylboronic acid

HCID 442494893-(3-chloropropyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide

생성물 1

HCID 685822151-(4-chlorophenyl)-3-(3-chloropropyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide

실험 절차

In an analogous manner to Example 1 step 7, 3-(3-chloropropyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide (468 mg) was coupled to p-chloro phenylboronic acid to provide 1-(4-chlorophenyl)-3-(3-chloropropyl)-3,4-dihydro-1H-2,1,3-benzothiadiazine 2,2-dioxide (50 mg):

출처 및 근거

ORD 기록: ord-b251b4f97b1d4c2bb20e70279306c976
출처 데이터셋: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07718652B2

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