Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
[2-(4-Chloro-benzoylamino)-thiazol-4-yl]-acetic acid → 4-chloro-N-{4-[2-(4-cyclohexylmethyl-piperazin-1-yl)-2-oxo-ethyl]-thiazol-2-yl}-benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | [2-(4-Chloro-benzoylamino)-thiazol-4-yl]-acetic acid | HCID 677042 | — |
| 반응물 | 1-(Cyclohexylmethyl)piperazine | HCID 2735885 | — |
| 생성물 | 4-chloro-N-{4-[2-(4-cyclohexylmethyl-piperazin-1-yl)-2-oxo-ethyl]-thiazol-2-yl}-benzamide | HCID 59698855 | — |
반응 단계
In analogy to example 1.3, [2-(4-chloro-benzoylamino)-thiazol-4-yl]-acetic acid (example 1.2) was coupled with (1-cyclohexyl-methyl)piperazine to give 4-chloro-N-{4-[2-(4-cyclohexylmethyl-piperazin-1-yl)-2-oxo-ethyl]-thiazol-2-yl}-benzamide, using general procedure A. Colorless amorphous solid. MS 461.0 ([M+H]+)
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07718659B2 |
| 출처 데이터셋 | uspto-grants-2010_05 |
| ORD ID | ord-830011cbbf394d3f998b084b8c11d0e6 |
| 출처 메모 | uspto-grants-2010_05 |