Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Benzene → N-acetyl-(R)-phenyl-alanine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Benzene | HCID 241 | — |
| 반응물 | 2-(Acetylamino)-3-phenyl-2-propenoic acid | HCID 95631 | — |
| 반응물 | HCID 178418361 | HCID 178418361 | — |
| 촉매 | cyclo-octadiene-((S)-1,2-Bis-(diphenylphosphino)-3-phenyl-propane)-rhodium-tetrafluoroborate | HCID 86738616 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | N-acetyl-(R)-phenyl-alanine | HCID 821174 | 99% |
반응 단계
There were added saturated solution of α-acetamido cinnamic acid in a mixture of 2 parts by volume of ethanol and 1 part by volume of benzene 7.9 mg of the catalyst produced in Example 12. The reaction mixture was sucked into an evacuated 100 ml autoclave and pressurized with 17 bars of hydrogen pressure. After working up in the manner as described in Example 6, there were isolated 4.4 grams of N-acetyl-(R)-phenyl-alanine having a rotary value of [α]D20 =-46.5° (c=1/95% EtOH), corresponding to an optical yield of 99%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04356324 |
| 출처 데이터셋 | uspto-grants-1982_10 |
| ORD ID | ord-008c63fd9da74710bae5d9f2cc8ef5fc |
| 출처 메모 | uspto-grants-1982_10 |