Ethane, 2-bromo-1,1-diethoxy- → 6-Bromo-8-fluoroimidazo[1,2-a]pyridine

반응식

[Br:1][C:2]1[CH:3]=[C:4]([F:9])[C:5]([NH2:8])=[N:6][CH:7]=1.[CH2:10](OC(OCC)CBr)[CH3:11]>>[Br:1][C:2]1[CH:3]=[C:4]([F:9])[C:5]2[N:6]([CH:10]=[CH:11][N:8]=2)[CH:7]=1

참가 물질

반응물 2

HCID 74852Ethane, 2-bromo-1,1-diethoxy-

HCID 508511302-Amino-5-bromo-3-fluoropyridine

생성물 1

HCID 220319336-Bromo-8-fluoroimidazo[1,2-a]pyridine수율 89%

실험 절차

Prepared from 5-bromo-3-fluoro-pyridin-2-ylamine (example C.29 step 3) (3.1 g, 15.7 mmol) and bromoacetaldehyde diethyl acetal (90%, 4.86 mL, 31.3 mmol) as described in example C.20 step 1. Obtained the title compound as a light brown solid (3.0 g, 89%). MS (ISP) 215.1 [(M+H)+], 217.1 [(M+2+H)+].

출처 및 근거

ORD 기록: ord-d8f7c0caa4ac470d8378be2747454ae4
출처 데이터셋: uspto-grants-2010_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07718661B2

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