Potassium Fluoride → HCID 22049881, 화합물

HRID 2238275노트

반응식

HRID 2238275 반응식
[CH:1]1([C:4]2[CH:9]=[CH:8][C:7]([S:10](Cl)(=[O:12])=[O:11])=[CH:6][CH:5]=2)[CH2:3][CH2:2]1.[F-:14].[K+]>CC(C)=O.O.CCOC(C)=O>[CH:1]1([C:4]2[CH:9]=[CH:8][C:7]([S:10]([F:14])(=[O:12])=[O:11])=[CH:6][CH:5]=2)[CH2:3][CH2:2]1

참가 물질

6

반응물 2

HCID 522689Potassium FluorideHCID 220498824-Cyclopropylbenzenesulphonyl chloride

생성물 1

HCID 22049881HCID 22049881, 화합물수율 97%

시약·촉매·용매 3

HCID 180Acetone용매HCID 962Water용매HCID 8857Ethyl Acetate용매

실험 절차

Crude compound 45 (13.3 g) was dissolved in 200 mL of acetone and 60 mL of water. Potassium fluoride (7.12 g, 122 mmol) was added and the reaction mixture was stirred overnight at rt. The reaction mixture was diluted with EtOAc and washed with water. The organic layer was dried with Na2SO4, filtered, and concentrated to dryness to give 9.80 g (97%) of crude p-cyclopropyl benzenesulfonyl fluoride (Compound 46).

후처리

  1. washwashed with water
  2. dry with materialThe organic layer was dried with Na2SO4
  3. filtrationfiltered
  4. concentrationconcentrated to dryness

출처 및 근거

ORD 기록
ord-64094a23f4df4a0c9adb03f5698ea394
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07718702B2

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