Water → 2,3-Dichloro-4-fluorobenzoic acid

HRID 2238509노트

반응식

HRID 2238509 반응식
[Cl:1][C:2]1[C:7]([Cl:8])=[C:6]([CH3:9])[CH:5]=[CH:4][C:3]=1[F:10].[Cr](O[Cr]([O-])(=O)=O)([O-])(=O)=[O:12].[K+].[K+].S(=O)(=O)(O)O.[OH2:27]>C(O)(=O)C>[Cl:8][C:7]1[C:2]([Cl:1])=[C:3]([F:10])[CH:4]=[CH:5][C:6]=1[C:9]([OH:12])=[O:27]

참가 물질

6

반응물 4

HCID 962WaterHCID 1118Sulfuric AcidHCID 24502Potassium DichromateHCID 67460080HCID 67460080, 화합물

생성물 1

HCID 103307052,3-Dichloro-4-fluorobenzoic acid

시약·촉매·용매 1

HCID 176Acetic Acid용매

반응 조건

온도
100 °C

실험 절차

2,3-dichloro-1-fluoro-4-methylbenzene (0.090 g, 0.5 mmol) was added to a stirred mixture of potassium dichromate (0.284 g, 1 mmol) in acetic acid (1 ml). 97% Sulphuric acid (0.5 ml) was then added slowly to the mixture which was subsequently heated at 100° C. for 2 hrs. After cooling to room temperature, water and ice were added and the green solid thus obtained was filtered off and washed with cold water to afford 2,3-dichloro-4-fluorobenzoic acid (0.056 g, 0.27 mmol) as a white solid.

후처리

  1. temperatureAfter cooling to room temperature
  2. customthe green solid thus obtained
  3. filtrationwas filtered off
  4. washwashed with cold water

출처 및 근거

ORD 기록
ord-c7130ab5c1c347fb92a2ad3621380524
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07718693B2

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