Diethyl Ether → HCID 57445526, 화합물

HRID 2238604노트

반응식

HRID 2238604 반응식
C1C=C[NH+]=CC=1.[O-][Cr](Cl)(=O)=O.[C:12]1([CH2:18][CH2:19][CH:20]2[C:24]3[CH:25]=[C:26]([CH2:29][OH:30])[CH:27]=[CH:28][C:23]=3[O:22][CH2:21]2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.C(OCC)C>C(Cl)Cl>[C:12]1([CH2:18][CH2:19][CH:20]2[C:24]3[CH:25]=[C:26]([CH:29]=[O:30])[CH:27]=[CH:28][C:23]=3[O:22][CH2:21]2)[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 23081965HCID 23081965, 화합물HCID 178418287HCID 178418287, 화합물

생성물 1

HCID 57445526HCID 57445526, 화합물수율 67%

시약·촉매·용매 1

HCID 6344Dichloromethane용매2회

실험 절차

To a suspension of PCC (3.69 g, 17.10 mmol) in methylene chloride (20 ml), a solution of 3-(2-phenylethyl)-2,3-dihydro-1-benzofuran-5-yl-methanol (3.32 g, 13.16 mmol) in methylene chloride (100 ml) was added at room temperature. After stirring for 12 h, diethyl ether (300 ml) was added and the black solid precipitated was filtered and washed with diethyl ether several times. The filtrate was concentrated under vacuum and the residue was purified by flash chromatography on silica gel (petroleum ether/ethyl acetate=95/5-9/1) affording 0.202 g of the title compound (67% yield).

후처리

  1. customthe black solid precipitated
  2. filtrationwas filtered
  3. washwashed with diethyl ether several times
  4. concentrationThe filtrate was concentrated under vacuum
  5. customthe residue was purified by flash chromatography on silica gel (petroleum ether/ethyl acetate=95/5-9/1)

출처 및 근거

ORD 기록
ord-3f71a010d1104ea2beb9844d82768eb3
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07718815B2

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