Ethanol → HCID 16112965, 화합물

HRID 2240926노트

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HRID 2240926 반응식
[F:1][CH:2]([F:21])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10](=O)[C:11]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15](O)C=2)=O)=[CH:6][CH:5]=1.Cl.[CH3:23][NH:24][C:25]([NH2:27])=[NH:26].[C:28](=[O:31])([O-])[O-].[Na+].[Na+].C([OH:36])C>>[NH2:26][C:25]1[N:24]([CH3:23])[C:28](=[O:31])[C:10]([C:7]2[CH:6]=[CH:5][C:4]([O:3][CH:2]([F:1])[F:21])=[CH:9][CH:8]=2)([C:11]2[CH:13]=[CH:18][CH:17]=[C:16]([OH:36])[CH:15]=2)[N:27]=1

참가 물질

5

반응물 4

HCID 702EthanolHCID 10340Sodium CarbonateHCID 59790334HCID 59790334, 화합물HCID 178485118HCID 178485118, 화합물

생성물 1

HCID 16112965HCID 16112965, 화합물수율 64%

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온도
85 °C

실험 절차

1-(4-(difluoromethoxy)phenyl)-2-(3-hydroxyphenyl)ethane-1,2-dione (0.11 g, 0.38 mmol) was dissolved in ethanol (5 mL). Methylguanidine hydrochloride (0.052 g, 0.47 mmol) was added followed by sodium carbonate (0.050 g, 0.47 mmol). The mixture was stirred at 85° C. overnight 15 hours. The solvent was removed and the material is absorbed onto celite. Purification by flash chromatography afforded 2-amino-4-(4-(difluoromethoxy)phenyl)-4-(3-hydroxyphenyl)-1-methyl-1H-imidazol-5(4H)-one (0.085 g, 64%).

후처리

  1. customThe solvent was removed
  2. customthe material is absorbed onto celite
  3. customPurification by flash chromatography

출처 및 근거

ORD 기록
ord-b977d5e6c5ba49fbbd2421b3273dbf91
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07723368B2

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