Diethyl Ether → 5-Ethynyl-2-fluorophenol

HRID 2240929노트

반응식

HRID 2240929 반응식
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][Si](C(C)C)(C(C)C)C(C)C)=[CH:4][C:3]=1[OH:20].[F-].C([N+](CCCC)(CCCC)CCCC)CCC.CCOCC>C1COCC1>[C:8]([C:5]1[CH:6]=[CH:7][C:2]([F:1])=[C:3]([OH:20])[CH:4]=1)#[CH:9]

참가 물질

5

반응물 3

HCID 3283Diethyl EtherHCID 2724141Tetrabutylammonium FluorideHCID 593053612-Fluoro-5-((triisopropylsilyl)ethynyl)phenol

생성물 1

HCID 593053355-Ethynyl-2-fluorophenol

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

2-fluoro-5-((triisopropylsilyl)ethynyl)phenol is dissolved in THF and tetrabutyl ammoniumflouride is added. The solution is stirred overnight at RT. Et2O is added and the solution is washed with H2O, Brine, dried, and the solvent removed. This material is used without any further purification.

후처리

  1. washthe solution is washed with H2O, Brine
  2. customdried
  3. customthe solvent removed
  4. customThis material is used without any further purification

출처 및 근거

ORD 기록
ord-aaa542c5d2664447b8f74091e6b99878
출처 데이터셋
uspto-grants-2010_05
특허 번호
US07723368B2

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