Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Acid → 6-Fluoro-8-{4-[1-(8-quinolinyl)-4-piperidinyl]-1-piperazinyl}quinoline
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Sodium triacetoxyborohydride | HCID 5049666 | — |
| 반응물 | 6-Fluoro-8-(piperazin-1-yl)quinoline | HCID 58975488 | — |
| 반응물 | 1-Quinolin-8-yl-piperidin-4-one | HCID 59204842 | — |
| 용매 | 1,1-Dichloroethane | HCID 6365 | — |
| 생성물 | 6-Fluoro-8-{4-[1-(8-quinolinyl)-4-piperidinyl]-1-piperazinyl}quinoline | HCID 12004112 | 45.4% |
반응 단계
To a solution of 0.247 g of 6-fluoro-8-piperazino-quinoline (Step 3) in 10 mL of dichloroethane, was added 0.226 g of 1-quinolin-8-yl-piperidin-4-one (Example A, Step 6, above) followed by 0.274 g of sodium triacetoxyborohydride and 0.1 mL acetic acid. The reaction was stirred at room temperature overnight. It was quenched with 1N NaOH, and the product was extracted with CH2Cl2. The organic phase was washed with water and dried over magnesium sulfate. The product crystallized and filtered to give 0.200 g of the desired product. Mp: 211° C.; MS (ES) m/z (relative intensity): 442 (M++−H, 100).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07671056B2 |
| 출처 데이터셋 | uspto-grants-2010_03 |
| ORD ID | ord-15e277b2b500461b9ea0927b56b83a7f |
| 출처 메모 | uspto-grants-2010_03 |