참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methyl isobutyrate | HCID 11039 | — |
| 반응물 | Cyclohexylisopropylamine | HCID 62386 | — |
| 반응물 | 1-Iodo-4-methoxybutane | HCID 22707894 | — |
| 반응물 | Butyllithium | HCID 178418339 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Hexamethylphosphoramide | HCID 12679 | — |
| 생성물 | HCID 21181993 | HCID 21181993 | 85% |
반응 단계
To N-isopropylcyclohexylamine (5.96 ml) in THF (30 ml) was added dropwise n-BuLi (1,6-M, 22.7 ml) at -78° C., and the mixture was stirred for 30 min, to which a THF (5 ml) solution of methyl isobutyrate (3.43 g) was added, and stirred at -78° C. for 45 min. Then, a HMPA (6.3 ml) solution of 1-iodo-4-methoxy-butane (9.05 g) was added to the mixture, and stirred at room temperature for 1 h to give methyl 2,2-dimethyl-6-methoxycaproate (4.81 g, 85%) after usual work-up.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05428062 |
|---|
| 출처 데이터셋 | uspto-grants-1995_06 |
|---|
| ORD ID | ord-e5728deaed1d48c68392a710194dac45 |
|---|
| 출처 메모 | uspto-grants-1995_06 |
|---|
