Phenylsulphonyl isocyanate → HCID 23332186, 화합물

HRID 224215노트

반응식

HRID 224215 반응식
[NH2:1][C:2]1[N:7]=[C:6]([N:8]([CH3:10])[CH3:9])[CH:5]=[C:4]([CH3:11])[N:3]=1.[C:12]1([S:18]([N:21]=[C:22]=[O:23])(=[O:20])=[O:19])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C(Cl)Cl.CC(C)=O>[CH3:9][N:8]([CH3:10])[C:6]1[CH:5]=[C:4]([CH3:11])[N:3]=[C:2]([NH:1][C:22]([NH:21][S:18]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)(=[O:20])=[O:19])=[O:23])[N:7]=1

참가 물질

5

반응물 2

HCID 76096Phenylsulphonyl isocyanateHCID 137293006,N4,N4-trimethyl-pyrimidine-2,4-diamine

생성물 1

HCID 23332186HCID 23332186, 화합물

시약·촉매·용매 2

HCID 180Acetone용매HCID 6344Dichloromethane용매

실험 절차

To a suspension of 15.2 g of 2-amino-4-dimethylamino-6-methylpyrimidine in 400 ml of methylene chloride at ambient temperature was added slowly 18.3 g of benzenesulfonylisocyanate. After stirring for four hours the mixture was stripped in-vacuo and the white semisolid residue triturated with ethyl ether and isolated by filtration. The solid was then slurried in hot acetone, cooled and refiltered to yield the solid named above which decomposed at 180°-182°.

후처리

  1. customthe white semisolid residue triturated with ethyl ether
  2. customisolated by filtration
  3. temperaturecooled
  4. customto yield the solid
  5. customdecomposed at 180°-182°

출처 및 근거

ORD 기록
ord-b4614a42cfa24a8fbd0ddc680ef7c32b
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04231784

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