Carbon Dioxide → 5-Chloro-2-methanesulfonylpyrimidine
반응식
[Cl:1][C:2]1[C:3](C(O)=O)=[N:4][C:5]([S:8]([CH3:11])(=[O:10])=[O:9])=[N:6][CH:7]=1.C(=O)=O>C1(OC)C=CC=CC=1>[Cl:1][C:2]1[CH:3]=[N:4][C:5]([S:8]([CH3:11])(=[O:9])=[O:10])=[N:6][CH:7]=1참가 물질
4
실험 절차
5-Chloro-2-(methylsulfonyl)pyrimidine-4-carboxylic acid (5.7 g, 24 mmol) was refluxed in anisole (8 mL) until the evolution of carbon dioxide ceased. The reaction mixture was cooled to room temperature and filtered. The solid was washed with light petroleum ether (1×50 mL) and dried to obtain the title compound (4.10 g, 88% yield) as a light orange solid.
후처리
- filtrationfiltered
- washThe solid was washed with light petroleum ether (1×50 mL)
- customdried
출처 및 근거
- ORD 기록
- ord-3fb86334fa384e0dab4ce14d98102812
- 출처 데이터셋
- uspto-grants-2010_03
- 특허 번호
- US07671043B2
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