Hydracrylonitrile → ethyl N-carbobenzoxy-N-[bis(beta-cyanoethoxy)phosphonomethyl]glycinate

HRID 224224

반응식

HRID 224224 반응식
[C:1]([N:11]([CH2:18][P:19]([O:23]Cl)([O:21]Cl)=[O:20])[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2].[C:25]([CH2:27][CH2:28][OH:29])#[N:26].C([N:32]([CH2:35][CH3:36])CC)C.[O:37]1CCC[CH2:38]1>>[C:1]([N:11]([CH2:18][P:19]([O:23][O:37][CH2:38][CH2:36][C:35]#[N:32])([O:21][O:29][CH2:28][CH2:27][C:25]#[N:26])=[O:20])[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2]

참가 물질

5

반응물 4

HCID 8011HydracrylonitrileHCID 8028Tetrahydrofuran2회HCID 8471TriethylamineHCID 54297302ethyl N-carbobenzoxy-N-(dichlorophosphonomethyl)glycinate

생성물 1

HCID 23332172ethyl N-carbobenzoxy-N-[bis(beta-cyanoethoxy)phosphonomethyl]glycinate

실험 절차

Ethyl N-carbobenzoxy-N-(dichlorophosphonomethyl)glycinate (11.7 g., 0.032 mole) and 2-cyanoethanol (4.52 g., 0.064 mole) were dissolved in tetrahydrofuran (50 ml). To this solution was added triethylamine (6.42 g., 0.064 mole) dissolved in 25 ml. of tetrahydrofuran. The resultant solution was stirred overnight at room temperature. The reaction mixture was then filtered and the filtrate concentrated in vacuo to yield ethyl N-carbobenzoxy-N-[bis(β-cyanoethoxy)phosphonomethyl]glycinate as a yellow oil, ND25 =1.05 and having the following analysis.

후처리

  1. dissolutiondissolved in 25 ml
  2. filtrationThe reaction mixture was then filtered
  3. concentrationthe filtrate concentrated in vacuo

출처 및 근거

ORD 기록
ord-e13ee0364e1244808fb144af690deaa4
출처 데이터셋
uspto-grants-1980_11
특허 번호
US04231782

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